Youkai Academy appears to be an ordinary boarding school, with the exception that its students are monsters learning to coexist with humans. All pupils attend in human form and study standard academic subjects, including literature, gym, foreign language, and mathematics. However, there is one golden rule at Youkai Academy: any human found on school grounds is to be executed immediately! Tsukune Aono is an average teenager who cannot get into any high school due to his poor grades. His parents inadvertently enroll him in Youkai Academy as a last-ditch effort to secure his education. As Tsukune unknowingly enters this new world, he encounters the most attractive girl on campus, Moka Akashiya. Deciding to stay in this perilous realm to further his relationship with Moka, he does not realize that beneath her beauty lies a menacing monster—a vampire. Rosario to Vampire is a supernatural school comedy that explores Tsukune's romantic exploits, experiences, and misadventures with a bevy of beautiful but dangerous creatures.