Cocoa Hoto is a cheerful, energetic girl who can befriend anyone in just three seconds. After moving in with the Kafuu family to attend high school away from home, she quickly becomes friends with Chino Kafuu, the shy and precocious granddaughter of the Rabbit House cafe's founder, who is often seen with the talking rabbit Tippy on her head. After starting work as a waitress in exchange for room and board, Cocoa also befriends another part-timer, Rize Tedeza, whose military upbringing has given her unusual behavior and significant physical capabilities; Chiya Ujimatsu, a waitress from a rival cafe who does everything at her own pace; and Sharo Kirima, a waitress at a different cafe who carries herself like a noblewoman despite being impoverished. Filled with fluffy silliness and caffeinated fun, Gochuumon wa Usagi Desu ka? is a heartwarming comedy about five young waitresses and their amusing adventures in the town they call home.