When a shapeshifting demon with a craving for human flesh, called a "youma," appears in Raki's village, a solitary woman with silver eyes enters the town carrying only a sword on her back. She is a "Claymore," a creature created as half-human and half-youma specifically to exterminate these monsters. After Raki's family is murdered, the Claymore saves his life, but he is subsequently expelled from his home. Having nowhere else to turn, Raki locates the Claymore, known as Clare, and chooses to accompany her on her missions. As the duo travels from town to town, slaying youma along the way, further details about Clare's organization and her fellow warriors are revealed. With each town purified and each demon eliminated, they draw nearer to the youma against whom Clare has sought vengeance since she decided to become a Claymore.