Masane Amaha and her daughter Rihoko are fleeing from a government child welfare agency that intends to remove Rihoko from her mother's care. They are apprehended, and Rihoko is taken away. Meanwhile, Masane is attacked by an advanced weapon capable of disguising itself as a human. Confronted with this danger, a strange light emanates from her wrist, causing her to transform into a powerful entity. She destroys the weapon and subsequently becomes embroiled in a power struggle between influential organizations, finding herself at the center of their attention. This occurs because she possesses the greatest power of them all: the legendary Witchblade.