In the early 1930s in Chicago, the transcontinental train Flying Pussyfoot begins its legendary journey, which will leave a trail of blood across the country. Meanwhile, in New York, the ambitious scientist Szilard and his reluctant aide Ennis search for missing bottles of an immortality elixir. Additionally, a war between mafia groups intensifies. On board the Advena Avis in 1711, alchemists are about to learn the price of immortality. Based on the award-winning light novels of the same name, Baccano! follows several events that initially appear unrelated in both time and place, yet form part of a much larger story involving alchemy, survival, and immortality. The kindhearted would-be thieves Isaac and Miria merge these events, connecting various people—each with their own hidden ambitions and agendas—and creating lifelong bonds and consequences for everyone involved.