In 1711, aboard the Advenna Avis, a group of alchemists summons a demon, hoping to gain eternal life. The demon gives them an elixir of immortality and the method for ending their existence by "devouring" one another. Soon after, one of them begins to devour his companions. Realizing the danger of staying together, they scatter across the globe. Centuries later, in 1930s America, a certain federal investigator tries his best to combat the rise of organized crime during Prohibition, send a particularly infuriating terrorist to Alcatraz, and catch an outrageous thief duo. Meanwhile, the transcontinental train, the Flying Pussyfoot, begins its trail of blood across the country. In 2002, a small group of the original Advenna Avis alchemists is on a journey to find the rest of their fellow immortals. However, there is one companion they did not expect to meet again. Seemingly unrelated events, from a sleepy Italian city in the early 1700s to a modern luxury cruise ship traveling across the Pacific, reveal themselves to be far more connected than anyone could imagine...