Following the events of Zero no Tsukaima: Princesses no Rondo, Saito Hiraga and Louise Françoise Le Blanc de La Vallière take the offensive. Alongside two others who command the power of the "void," they confront King Joseph in the Holy City of Romalia. Yet, amidst the numerous conflicts that lie ahead, an ancient evil begins to stir in the shadows. Will their close bonds blossom into something more, or will they be shattered by the ever-increasing difficulty of the tasks they must undertake? Zero no Tsukaima F follows the story of Louise and Saito as they face their final challenges together.