In the 1960s, a talented young medical student attempts to establish his reputation. Kuroo Hazama is a reserved young man with distinctive black-and-white hair, a body marked by scars, and a dark past. Although he is merely a medical student, his surgical skill begins to draw attention after he performs an operation that seems impossible. Alongside the energetic and honest intern Maiko Okamoto and Yabu, a close friend with a troubled life, Hazama dedicates himself to the field of medicine. However, his road to becoming a respected surgeon is arduous, as student riots, war, and corruption engulf Japan. Hazama soon finds himself entangled in a series of sinister circumstances that test his personal integrity and his path toward becoming a surgeon. Young Black Jack chronicles the story of a man capable of performing unthinkable medical feats, and the journey that leads him to become the legend known as Black Jack.