There once lived a vampire named Vanitas, despised by his own kind for being born under a full blue moon, whereas most emerge on the night of a crimson one. Fearful and isolated, he created the Book of Vanitas, a cursed grimoire destined to exact his vengeance on all vampires; so the tale goes, at least. Vanitas no Karte follows Noé Archiviste, a young man traveling aboard an airship in 19th-century Paris with a single objective: to locate the Book of Vanitas. A sudden vampire attack leads him to encounter the enigmatic Vanitas, a doctor specializing in vampires and, much to Noé's surprise, a completely ordinary human. This mysterious physician has inherited both the name and the notorious text from the legendary Vanitas, employing the grimoire to treat his patients. Yet, beneath his gentle demeanor lies something somewhat more sinister.