Atsushi Nakajima is on the verge of death after being expelled from his orphanage. With no food and nowhere to go, all hope seems lost—until he saves a mysterious man named Osamu Dazai from drowning. Much to the irritation of his partner Doppo Kunikida, Dazai gives Atsushi a meal and reveals that they work for the Armed Detective Agency, an organization of gifted individuals who handle criminal cases the authorities cannot. The two ask Atsushi for his help in tracking down a supernatural tiger that has been wreaking havoc throughout the city, and he reluctantly agrees. After they resolve the case, Dazai offers him a position in the agency. But the job is about to get a lot more dangerous as the Port Mafia, the local crime syndicate, begins to move against them. Caught in the middle of a turf war, Atsushi must master his newfound special ability in order to protect himself, his new friends, and the entire city.