The great detective Holmes does not solve mysteries or employ deductive reasoning. He does, however, hunt vampires. Through three-minute episodes, Vampire Holmes recounts the tale of the great Holmes and his assistant. What starts as a standard detective agency shifts toward the occult when the Metropolitan Police of London secretly hire Holmes and Hudson to investigate vampires. Or at least that is what Holmes would claim to anyone who asks. In truth, he and Hudson spend most of their time sitting around arguing, and failing to solve any cases. Joined by the not-so-black demon cat Kira, and their terrifying, rent-hungry landlady, this is the story of the man who was most definitely not London's greatest detective.