Two and a half years after the dark day of the Lost JuLai, Meryl Stryfe wanders through the desert wilderness of Noman's Land with her younger assistant, Milly Thompson. She continues to hunt Vash the Stampede, the culprit responsible for the cataclysmic events that killed 90 percent of JuLai city's population. Vash, also known as the "Humanoid Typhoon," is now wanted for 60 billion double dollars—the largest bounty in the planet's history. In a remote town in Noman's Land, an apathetic Vash has been rescued and tended to by Hoppered the Gauntlet, a man who conceals his mutilated body with armor. However, Hoppered's secluded existence is suddenly disrupted by the arrival of young Jessica, who seeks help for her endangered home.