In 1939, humanity stood on the brink of destruction. Armed with weapons of devastating power, a mysterious alien race known as the Neuroi launched an invasion of Earth, ravaging the planet, obliterating countries, and vanquishing human armies. To counter this seemingly unstoppable force, the world's powers united. A new device, called the Striker Unit, was produced, capable of facing Neuroi technology. Girls equipped with the Striker Unit became known as the Witches, forming humanity's last line of defense. They began their fight against the Neuroi, utilizing their now-enhanced magical abilities and flaunting destructive weapons no human could manage. Fast forward to 1944—Yoshika Miyafuji is a young teenage girl who eventually decides to join the 501st Joint Fighter Wing, known as the "Strike Witches." With no formal training, however, can Miyafuji learn to cooperate with her fellow Strike Witches? And if so, can she save humanity from the Neuroi onslaught?