Momo Minamoto is a timid teen who simply wishes to do good in the world. Her dream is to follow in her police officer father's footsteps and uphold law and order. And just like him, she possesses a very unique ability: her senses are far more refined than those of any average person. A simple lick allows her to determine what someone is feeling. One night, while admiring the landscape, Momo spots suspicious figures moving in the distance. After discovering that these figures are spies, she is recruited by their captain, Yuki Hanzoumon, a senior at her school. The members of their secret agency, known as the Tsukikage, also have the power to gain strength after ingesting spices. Release the Spyce is an action-packed spy series about the Tsukikage's missions as they fight in the shadows to protect the city from crime while balancing their high school life.