At first glance, Galko, Otako, and Ojou appear to be three high school girls who would have nothing in common. Galko is a social butterfly known as a party animal, yet she is actually innocent and good-hearted despite her looks. Otako is a plain-looking girl with a sarcastic personality and a rabid love of manga. Ojou is a wealthy young lady with excellent social graces, although she can be a bit absent-minded at times. Despite their differences, the three are best friends, and together they enjoy discussing various myths and asking candid questions about the female body. Oshiete! Galko-chan offers a lighthearted and humorous look at three very different girls and their frank conversations about themselves and everyday life. No topic is too safe or too sensitive for them to joke about—even though every so often, Galko seems to get a bit embarrassed by their discussions!