Long ago, the "nobles" existed, an ancient race of immortal supernatural beings who were revered as rulers and gods. Among them was the "Noblesse," a powerful and mysterious figure named Cadis Etrama di Raizel, or "Rai." After waking up in South Korea from an 820-year slumber, Rai sets out to find his loyal servant, Frankenstein, whom he discovers is now the director of Ye Ran High School. To learn more about modern civilization, Rai enrolls as a student to better experience life in the contemporary world. Noblesse: Awakening details the start of Rai's new life as a high school student, as he spends time with friends and battles both human and supernatural threats to stop their schemes from harming Korea.