At the start of World War III, no one could have foreseen its impact on Japan. Although the conflict officially concluded fifty years prior, in 2150, its battles continue. Vast, enigmatic zones dubbed "Blackspots" have emerged throughout the nation, containing the polluted remnants of urban and rural landscapes. Individuals within these areas were confined to prevent the spread of contamination, and their abilities began to mutate—whether they were shapeshifters, pyromancers, or gravity manipulators—they all came to be known as the Needless. Adam Blade is one such Needless, endowed with exceptional regenerative powers and immense strength. To bring peace back to a war-ravaged Japan, he and his companions must unite to oppose a vile research organization called Simeon.