Suddenly, parasitic aliens descended upon Earth, quickly infiltrating humanity by burrowing into the brains of vulnerable targets. These insatiable beings acquire full control of their hosts and can morph into various forms to feed on unsuspecting prey. Sixteen-year-old high school student Shinichi Izumi falls victim to one of these parasites, but it fails to take over his brain, ending up in his right hand instead. Unable to relocate, the parasite, now named Migi, has no choice but to rely on Shinichi to stay alive. Thus, the pair is forced into an uneasy coexistence and must defend themselves from hostile parasites that hope to eradicate this new threat to their species.