After inadvertently taking part in a kidnapping, college student Yuuya Nomoto discovers that his friends have been brutally murdered by Hitomi Uzaki, the high school girl they had tried to abduct. Compelled to drive her to an unknown location, he is wagered as the prize in a death match between two Therianthropes, superpowered human-animal hybrids produced via advanced gene therapy. As one of these hybrids, Hitomi employs the speed and fearlessness derived from her ratel genes to viciously defeat her opponent and save Yuuya from certain death. Waking up hours later, hoping the entire incident was merely a nightmare, Yuuya realizes he has become entangled in a secret proxy war among four major Japanese business conglomerates, with the victor set to control the economy. As her only, albeit unwilling, investor, his life is now directly tied to Hitomi's capacity to compete in underground bloodsport matches known exclusively as Killing Bites.