Sentenced to death, the ninja Gabimaru the Hollow feels apathetic. Having led a life steeped in blood, Gabimaru believes he deserves to die. Yet, every attempt to execute him inexplicably fails. Ultimately, Sagiri Yamada Asaemon, a novice from a renowned clan of executioners, is tasked with taking Gabimaru's life; however, Sagiri does not kill him as ordered. Sagiri insists that Gabimaru will not die due to his love for his wife and instead offers him a chance to secure a full pardon for his crimes. If he travels to the island of Shinsekyo, obtains the Elixir of Life—which is said to grant immortality—and brings it back for the shogun, his freedom will be guaranteed. However, of the many who have journeyed to Shinsekyo in search of the mythical Elixir, not a single person has returned with their sanity intact, if they have returned at all. Though unaware of the numerous dangers that lie ahead, Gabimaru decides to accept the offer—along with ten other death row inmates—in the hope that he and his wife may finally live in peace.