Pushed to the brink of extinction by the "Aragami," a race of all-devouring monsters, humanity makes its final stand in isolated pockets of resistance. Immune to conventional damage, these creatures can only be killed by "Oracle Cell" weapons, which are composed of the same matter that makes up the Aragami. However, thanks to their god-like ability to adapt, the Aragami soon develop further immunity. With no other hope of repelling the enemy, the remnants of human governments decide to detonate a nuclear reactor to wipe out the monsters threatening Eurasia. The soldiers assigned to this mission are aided by three "God Eaters" dispatched from the Fenrir Far East Branch, an organization that controls what remains of Japan. They wield state-of-the-art weapons known as God Arcs, which are supposedly capable of piercing Aragami skin and tearing out their cores, pulverizing the monsters. These mighty warriors may well be humanity's last hope of fending off the Aragami threat and averting total extinction.