After being struck by a truck in 2014, Akira Natsume wakes up to find himself inside a machine following a 16-year coma. As he gets used to the new interface, he is met by police officer Minami Uezono and her android partner, Alma. The duo shows Akira that his brain is housed within a device known as an EX-ARM—a weapon of mass destruction. Onboard an enemy smuggler's ship, the trio must escape relying solely on their ingenuity and combat skills. Although initially hesitant to fight, Akira soon remembers his brother's words from before the accident. This memory inspires him to take action, possessing Alma's body to battle his opponents using martial arts. Once Alma connects him to one of the ship's ports, he uncovers the devastating potential of his EX-ARM by effortlessly hacking and taking control of the vessel. Upon safely returning to land, Akira meets the other members of the EX-ARM Countermeasure Prevention Team, a police division dedicated to mitigating the effects of EX-ARMs. Witnessing the atrocities committed by those seeking the power of EX-ARMs, he decides to join the team and put an end to the terror caused by these weapons.