Tucked away in Tokyo's Asakusa district stands a quiet mansion called Ayakashi-sou. Although it is large, the residence houses only one sixteen-year-old girl. Yet, the name Ayakashi-sou comes from the ayakashi—Japanese spirits and ghosts that dwell there. Kuuko and Yukime, a prank-loving fox girl and a gentle snow-woman, make this place their home, while the childlike Zashikiwarashi Kii keeps watch over the building. They are soon joined by Nene, a newly created cat youkai who has nowhere else to go. The building's owner, Mahoro Miyatsuka, lives with the ayakashi. She inherited the property from her late grandmother because of her ability to see and interact with spirits. While this ability lets Mahoro connect with the ayakashi, her habit of talking to invisible people has caused her peers to avoid her. Despite this, Mahoro is content caring for her ghostly friends as they spend their days watching fireworks, playing games, and otherwise taking life one day at a time.