Anhe, the world's most enigmatic assassin organization, comprises the Su, Xie, and Mu clans. With everyone poisoned and their lives hanging in the balance, the three factions along the Anhe River seized the chance to stage a rebellion. Su Muyu, leader of the Spider Shadow guard, recruited Bai Hehuai, the prodigy physician from Medicine King Valley, to treat the elders. While fending off assassins and safeguarding Elder Zhouquan, he acted alongside his friend Su Changhe, who was in Anhe but had joined the plot to assassinate the patriarch on behalf of the Su family.