This is a lengthy, epic manga covering three generations of the Etou family. The initial section centers on Ranze, a fairly ordinary high school student, save for the fact that her father is a vampire, her mother is a werewolf, and she possesses her own magical abilities. Her family was exiled from the Magic World to reside among humans, and they currently guard the gate separating the two realms. The narrative truly kicks off when Ranze falls for a human boy, a relationship her parents strictly prohibit. Subsequent story arcs focus on Ranze's brother and on Ranze's daughter.