Nagisa Aoi starts her new school life as a transfer student at St. Miator’s Girls Academy, one of three prestigious all-girls schools located atop Astraea Hill. After getting lost on her first day, Nagisa meets a mysterious student whose elegance and charm are so bewitching that she ends up in the infirmary. Upon waking, she is greeted by Tamao Suzumi, her roommate, who enthusiastically introduces Nagisa to the daily life and social structure on campus. Most notably, Tamao tells her about the existence of an exceptional student representative among all three schools—the Etoile, or "star." Eager to meet this person, Nagisa discovers that the ethereal beauty she encountered earlier, Shizuma Hanazono, is the one and only Etoile! Not only that, Shizuma seems openly interested in Nagisa! Her interactions with Shizuma naturally make her a hot topic on campus; yet, despite being so captivated, Nagisa can’t help but wonder if something is off. Strawberry Panic! follows the everyday routines of Nagisa, Shizuma, and their friends at St. Miator’s, St. Spica, and St. Lulim as they navigate the challenges of relationships while confronting hidden feelings, lingering regrets, and new possibilities.