Speed Grapher chronicles the exploits of Tatsumi Saiga, a former war photographer who investigates a secret fetish club catering to the ultra-wealthy. He attempts to photograph the club's "goddess", a 15-year-old girl named Kagura, but is discovered. Just as he is about to be killed, Kagura kisses him, granting him the ability to destroy anything he photographs. Kagura's body fluids can give people bizarre abilities related to their fetishes or obsessions. The story develops as Saiga aims to grant Kagura's desire (her freedom), while on the run from the Secret club and the Tennouzu Group mega-corporation that operates it.