Death City houses the Death Weapon Meister Academy, founded by Shinigami—the grim reaper himself. Established to uphold peace, the academy trains Meisters and Demon Weapons—individuals who assume the form of a weapon—to safeguard humanity from evil. A Meister's ultimate objective is to forge a "Death Scythe" fit for Shinigami to wield. To achieve this, their weapon partner must devour the souls of 99 wicked humans and one witch. Maka Albarn and her partner Soul Eater "Soul" Evans are two students aspiring to create a Death Scythe. They are accompanied by the boisterous Black☆Star and his partner Tsubaki Nakatsukasa, as well as the perfectionist Death the Kid—simply called Kid—and his partners, the twins Patricia "Patty" and Elizabeth "Liz" Thompson. These ambitious students all strive to become the ultimate Meister and Demon Weapon team, navigating misadventures, missions, and numerous class trials. However, numerous mysteries envelop them, and as new foes emerge and secrets come to light, Maka, Soul, and their friends must battle to shield the academy, Death City, and the world itself from adversaries far more dangerous than humans.