Sansha Sanyou centers on three comedic characters: Futaba Odagiri, a new transfer student with a highly energetic personality; Teru Hayama, the class president whose surprisingly mean nature contrasts with her innocent appearance; and Youko Nishikawa, who comes from a formerly wealthy but now extremely impoverished family yet maintains her princess-like attitude. These three unlikely students, with their clashing personalities, become good friends and navigate daily teenage life in a very funny story.