Saint☆Oniisan is a slice-of-life or divine-life tale of Jesus and Buddha as they attempt to experience the modern world, specifically Japan. The manga offers a humorous take on religion, attitudes, culture, and customs in Japan through the perspectives of Jesus and Buddha. Jesus and Buddha are shown experiencing Asakusa, public baths, theme parks, and the internet. Throughout the manga, brief glimpses of their divine greatness are presented, only to highlight their apparent insignificance in modern Japanese society. Suffice it to say, before people realize they are actually Jesus and Buddha, they are mistaken for someone resembling Johnny Depp or a man with a button on his forehead. For real.