Tokyo was reduced to ruins by the successive major earthquakes of 2014. Consequently, the new city center was established in the area of the former Nishitokyo. Meanwhile, Shinjuku and the submerged Minato wards deteriorated into slums. Furthermore, driven by the Immigration Laws of 2040, these slums experienced an influx of refugees, mafioso, and terrorists, becoming the world's leading crime capital. It is now 2049, and this is the setting for an operation in which two women set out to arrest a dangerous drug dealer.