Daimon Kaito, a puzzle fanatic, has been obsessed with solving brain teasers, puzzles, and riddles his entire life. He attends the prestigious Root Academy alongside Nonoha, though he spends most of his time creating and solving puzzles. Kaito is one of the few genius teenagers at the school to have been awarded the title Einstein, joining other equally brilliant classmates who hold the titles Galileo, Edison, and Da Vinci. Together, they attempt to solve a puzzle that has remained unsolved since its creation centuries ago. However, the genius students soon realize that dangerous forces lie behind the impossible puzzle.