In this sequel series, events continue four years after the first series concluded. Papuwa-kun is a mysterious boy living on a new tropical island populated by the same bizarre creatures. Together with his maid, Liquid, and his new amnesiac friend, "Rotarou", they embark on nonsensical adventures while attempting to evade and confuse the Ganma Army, Special Corps, and even the Shinsengumi, who seek to uncover Rotarou's true secret and take him away.