Miko Yotsuya is an ordinary high school student whose existence is upended when she abruptly begins to perceive grotesque and repulsive monsters. Although utterly terrified, Miko persists in her routine, feigning ignorance of the terrors encircling her. She endures this dread to safeguard herself and her friend Hana Yurikawa from harm, even if it requires confronting the most dreadful entities. Combining comedy with horror, Mieruko-chan chronicles a girl who attempts to manage the paranormal by maintaining an indifferent facade.