Following a bizarre hostage situation, SWAT officer Linda and her friend Mary, a CSI division employee, find that the culprit has contracted a mutated rabies virus from the hostage's dog, which is now roaming free. Before long, the city is overrun by people transformed into monsters by the disease, and to their horror, Linda and Mary's mutual friend Kata, a stripper at the local nightclub, seems to have been bitten by the stray dog as well...