What connects two Japanese detectives, a naked man on a city street, and a roundworm from Botswana? In the first volume of Manhole, Ken Mizoguchi and Nao Inoue investigate a series of bloody and mysterious murders, but their work uncovers a deadly biological agent that poses a threat of epidemic proportions. An unlikely lead sets them on the trail of a mysterious self-titled photographer, but meanwhile the infections keep spreading. The series may be best described as the thrilling combination of a detective story with biological horror.