Following a long period of unrequited love, Yasuke Arahabaki intends to finally confess to his childhood friend, Akari Inamori, when she visits his home for a meal. However, just before dinner, his older sister asks him to clear the weeds at their family shrine's temple. Nervous about the upcoming confession, he accidentally shatters the shrine's sacred mirror. As a dire consequence, a girl bursts out of the mirror, extracting Yasuke's soul and killing him. The girl then kisses him, bringing him back to life. However, it turns out that the girl, Seoritsuhime, is a goddess of misfortune who holds Yasuke's soul along with a curse: if they were to separate, Yasuke would die once more. Maga-Tsuki tells the story of an unfortunate man, a goddess of misfortune, a childhood friend, and the god above all other gods in their efforts to return their lives back to normal. But will this be an easy task, or will love stand in their way?