Civil war rages in the country of Gazth-Sonika. There, a mercenary named Madlax works with almost supernatural skill. In the seemingly peaceful country of Nafrece, Margaret Burton lives a tranquil life. Though their lives may seem separate, the two are connected by mysterious ties and by a holy book that the shadowy organization Enfant also seeks. As Margaret and Madlax follow the path of their destiny, they come ever closer to uncovering the truth—with no guarantee that it is a truth they can bear to learn.