Following a lengthy absence, the young shaman Samizo Kohei rises from the dead bearing an apocalyptic prophecy. Or rather, a fragment of him does—most of his physique now consists of transplanted organs from his former friends, each retaining its distinct personality. He comes back to his Shinjuku residence, operating as a psychic surgeon in an unlicensed clinic. In this capacity, he acts as the unofficial protector of the Shinjuku underground, resolving paranormal murder cases with the aid of various eccentric mystics and semi-human associates. Meanwhile, others question what Kohei has turned into, and whether his return aims to avert the apocalypse or trigger it.