Kimi wa Girlfriend centers on a girl named Hatsune who has a "bad mouth," or so it seems. She is kind-hearted, but her words express the exact opposite of her intentions (likely because she was raised with only male influence). Consequently, she is viewed as an arrogant and vulgar student at her school, yet all she desires is a boyfriend. That changes when she joins the Maidens' Club and meets a boy named Kirie, who has a peculiar habit triggered whenever a girl comes within a foot of him. Everyone, including Hatsune, assumes he is gay. How will these two get along? Will Hatsune finally get a boyfriend? Will he be more than just a friend?