In an era of technological advancement, only women can pilot the most advanced military unit ever created—the Infinite Stratos (IS). Leveraging this capability, women have taken complete control of all political, social, and economic endeavors, relegating men to the margins of society where they must cater to the whims of their new female overlords. This status quo shifts when Orimura Ichika, the only male discovered to possess IS piloting ability, is thrust into the spotlight and enrolled at the prestigious IS Academy. Surrounded by a female-dominated population, Ichika aims to demonstrate that men still have a place in this world. He has no idea that he is exactly what these women have been searching for.