Tsukushi Makino, a girl from a working-class background, enrolls in Eitoku Academy, an elite institution attended by children of wealthy, high-society families. She is regarded as the school's "weed," standing out among the affluent students, including the "Flower" Four (F4). Tsukasa Domyoji, the F4 leader and heir to Japan's wealthiest and most powerful family, becomes interested in Tsukushi because she is the only girl at Eitoku who does not fawn over him. However, his hot-headed temperament and bullying behavior initially repel Tsukushi, who has her sights set on someone else.