Ponta is a Labrador retriever puppy belonging to the Koizumi family. She is energetic and typically gets into mischief. However, trouble arises when Grandpa Koizumi, an amateur inventor, creates the Guruguru Bone and Ponta's curiosity leads her to nibble it, transforming her into a human girl. Surprised but undaunted, Ponta leaves the house and encounters Mirai Iwaki, the school's most popular boy. After Mirai saves her from a speeding car, Ponta reverts to her puppy form. Nevertheless, her brief experience as a human has changed her; her heart races and her face flushes when she thinks of Mirai, as she is now in love. Using the Guruguru Bone's power, Ponta switches back and forth between dog and girl, but can she win Mirai's affections?