Following the defeat of Mazinger Z, Great Mazinger serves as the continuation of the successful manga and anime series. Tetsuya Tsurugi takes on the role of the new protagonist, piloting the powerful Great Mazinger, which was created by Kenzo Kabuto, Koji Kabuto's father, who was previously believed to be dead. The antagonists in this installment are the Mycene Empire and its formidable robots.