Irene Lapona may possess a youthful face and a gentle physique, but when she applies makeup, she can completely transform her appearance to look however she wishes. Gorgeous, yet "so sadistic," Irene works as a professional assassin in her spare time. Despite her skill, when another assassin targets her for revenge, she confronts the most difficult battle of her life. In distinct settings of time and space, three separate stories unfold. In the Wild West, a historic poker game is set to take place between two of its most notorious outlaws, who are as unmatched in skill as they are in deception. Far away in the deep reaches of space, a two-man freighter crew finds itself at the beginning of an endless game of survival when a mysterious outsider plants a bomb on their ship. Finally, in a sleepy little town, the clever young swindler B.T. discovers that he must put all his tricks to the test when the object of his affection comes into harm's way. In Gorgeous☆Irene, Hirohiko Araki, the mastermind behind JoJo no Kimyou na Bouken, brings together a collection of tales featuring gamblers and tricksters, along with "heroes" who throw righteousness straight out the door.