Doujin Work follows the life of a young girl named Najimi Osana and her entry into the doujin world. She was first tempted to become a doujin artist after seeing how much one of her friends could earn at a convention. Najimi loves to draw, but soon learns, contrary to her expectations, that this new world is anything but easy. As she attends more conventions and meets more people, Najimi eventually manages to find a group of very interesting friends. These friends already have some experience in the field and help her along the way so that she can someday make a name for herself creating doujinshi.