Once, there was an explosion... The lonely souls of the dead manifest in the physical world, reaching out in search of the living. However, the connection they create triggers a massive explosion that eradicates anything of this world—a phenomenon referred to as the Death Stranding. These events wipe out nations as well as civilization itself. The people who remain are now isolated, withdrawn, and without connections. As humanity stands at the brink, a legendary porter sets out to transport both cargo and the wishes of its senders, reconnecting people in the hope that they might still be saved. Somewhere in North America, just as Sam Bridges walks through the continent in order to save America, the others are also trying to deal with their isolation in their own way. An old man trying to realize salvation through ways outside of the connection advocated by Bridges. A female warrior who tries to kickstart a world of constant fighting. A boy with a grudge against Bridges. A girl who embraces loneliness. On the precipice of the end of humanity and the world, their fates and hopes converge, as another story of Death Stranding begins. And now, comes another explosion...