High school student Kaname Sudou receives an invitation link from a friend to play a brand-new mobile game titled Darwin's Game, unaware that it will alter his life permanently. Initially, the game appears to be a standard fighting title. Yet, it harbors a grim secret: the matches are one-on-one, and the defeated player dies in reality. Shortly after entering the game, Kaname is suddenly paired with his first opponent. Despite the unfavorable odds, he miraculously emerges victorious. Fearing this new reality, Kaname seeks a way to quit the game and resume his normal routine. However, the only apparent solution is to win every assigned battle. Kaname must now determine how to survive and attempt to locate allies he can rely on.