Set in the Send-Off Department of the Japanese Angel Federation, Dandelion follows "Angels" Tetsuo Tanba and Misaki Kurogane as they rush to track down Earthbound spirits—souls unable to move on and find peace—and gently guide them to pass on. The angels find themselves struggling to meet their daily tasks. However, Tetsuo Tanba and his leader, Misaki Kurogane, who make up the 21st Division's Dandelion Clan, chose to take things at their own pace: instead of rushing through cases, they take time with each spirit, listening to their regrets and helping them resolve what's holding them back. One day, they encounter the Earthbound spirit of an elderly man who is running at full speed, trying desperately to escape.