The galactic group contains over 100,000,000,000 galaxies, with the Milky Way—home to Earth's solar system—being just one among many in the vastness of outer space. The narrative begins in 3199, when a powerful foe launches an attack on the Milky Way from a neighboring galaxy. This enemy confronts the combined forces of the Milky Way, an Alliance comprising numerous stellar nations, and defeats them sequentially. The surviving forces of the Milky Way Alliance are whittled down to merely six fleets. Following the destruction of the Alliance headquarters and as the central command faces imminent collapse, the Great Yamato "Zero" takes everyone by surprise and sets out on a mission to aid the Milky Way Alliance in a final, decisive battle.